I think I would like to have the profile with username on the top left, the buttons for add a friend, message etc. on the top right, the bio on the left and all the other stuff (name, email, birthday, schools, memories etc.) in a floaty box down the right. Beneath all that would be the friends/comms/feeds stuff.
However, if all the misc stuff needs to go across the top, then...
Current Beta:
My Quickie Alternative:
Please note that it is now early morning and I didn't bother spending much time doing the mock up.
On one hand, yeah, the old profile works fine and why mess with that? On the other hand, I love redesigns done right. An example of this would be DeviantART - they just launched version 6 of the site and...me like :)